Pain & Headache

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Study

Psilocybin Microdoses May Extend Cluster Headache Remission

Psilocybin Microdoses May Extend Cluster Headache Remission

Psilocybin mushrooms

What they found

In a case series, most patients using psilocybin, LSD or ketamine reported dramatic drops in cluster headache severity and frequency.

In a case series, most patients using psilocybin, LSD or ketamine reported dramatic drops in cluster headache severity and frequency.

How solid is it?

Early human

Early human

Human – case report

Human – case report

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin, LSD, ketamine

psilocybin, LSD, ketamine

Published in

Cephalalgia Reports

Cephalalgia Reports

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Cluster Headache Relief

Cluster Headache Relief

This case series explored real-world use of psilocybin, LSD, and ketamine in treating cluster headaches, one of the most painful and treatment-resistant neurological conditions. Most patients reported dramatic reductions in headache severity and frequency. For psilocybin, sub-hallucinogenic “microdoses” were especially effective in extending remission.

This case series explored real-world use of psilocybin, LSD, and ketamine in treating cluster headaches, one of the most painful and treatment-resistant neurological conditions. Most patients reported dramatic reductions in headache severity and frequency. For psilocybin, sub-hallucinogenic “microdoses” were especially effective in extending remission.

Psilocybin for Awe, Mycelium vs. Oil, and a Supplement Wake-Up Call

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