Mood & Mental Health

·

Study

Psilocybin Microdosing Trial: Less Anxiety, No Depression Change

Psilocybin Microdosing Trial: Less Anxiety, No Depression Change

Psilocybin mushrooms

What they found

In a double-blind trial, 2 mg psilocybin weekly for 8 weeks didn't significantly change depression but reduced anxiety.

In a double-blind trial, 2 mg psilocybin weekly for 8 weeks didn't significantly change depression but reduced anxiety.

The number

2 mg of psilocybin weekly for 8 weeks

How solid is it?

Early human

Early human

Human – RCT

Human – RCT

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

McMaster University

McMaster University

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Microdosing Breakthrough

Microdosing Breakthrough

A gold-standard double-blind trial from McMaster University tested 2 mg of psilocybin weekly for 8 weeks in adults with mild-to-moderate depression. While depression scores didn’t significantly change, participants reported reduced anxiety and improved quality of life—without cognitive impairment. This study redefines microdosing as an unimpairing dose and sets a new benchmark for research in real-world mental health applications

A gold-standard double-blind trial from McMaster University tested 2 mg of psilocybin weekly for 8 weeks in adults with mild-to-moderate depression. While depression scores didn’t significantly change, participants reported reduced anxiety and improved quality of life—without cognitive impairment. This study redefines microdosing as an unimpairing dose and sets a new benchmark for research in real-world mental health applications

Microdosing Breakthrough, Reishi vs. Aging, and Fungi Protein

Read the original study ↗

Get Shroom Scan

Next study

New Hampshire Committee Advances Psilocybin Decriminalization ›

Shroom Scan · Every Friday

Get Studies Like This, Translated, Every Week

Ten new studies a week, each boiled down to what it found and why it matters to you. Free, and one click to leave.

See what's inside →