This study used advanced mass spectrometry to compare five psilocybin mushrooms (like Texas Yellow and Blue Meanie) with three edible types (like shiitake and button mushrooms). It found that psilocybin mushrooms have a completely distinct chemical profile, with unique alkaloids that may enhance therapeutic effects beyond psilocybin alone. The work highlights the “entourage effect” and sets a foundation for future classification, safety, and clinical use of whole mushrooms.