Mood & Mental Health

·

Study

Psilocybin Outpaced Prozac in Stressed Mice

Psilocybin Outpaced Prozac in Stressed Mice

Psilocybin mushrooms

What they found

Psilocybin reversed depressive-like behavior in stressed mice within 24 hours, lasting 14 days, far faster than fluoxetine.

Psilocybin reversed depressive-like behavior in stressed mice within 24 hours, lasting 14 days, far faster than fluoxetine.

The number

within 24 hours

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin; fluoxetine; ketamine

psilocybin; fluoxetine; ketamine

Published in

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Fast-Acting Relief

Fast-Acting Relief

In a head-to-head comparison, psilocybin reversed social withdrawal and depressive-like behaviors in stressed mice within 24 hours, with effects lasting 14 days—far outpacing the standard antidepressant fluoxetine, which required two weeks to work. Ketamine showed similar rapid and durable benefits.

In a head-to-head comparison, psilocybin reversed social withdrawal and depressive-like behaviors in stressed mice within 24 hours, with effects lasting 14 days—far outpacing the standard antidepressant fluoxetine, which required two weeks to work. Ketamine showed similar rapid and durable benefits.

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