Mood & Mental Health

·

Study

Psilocybin Plus CBT Brought Remission to Over Half of Patients

Psilocybin Plus CBT Brought Remission to Over Half of Patients

Psilocybin mushrooms

What they found

In 16 adults with major depression, psilocybin-assisted CBT led 56% to full remission, sustained at 3 months.

In 16 adults with major depression, psilocybin-assisted CBT led 56% to full remission, sustained at 3 months.

The number

56% (9 of 16) reached full remission

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

16 adults

16 adults

Published in

Journal of Affective Disorders

Journal of Affective Disorders

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

CBT-enhanced Response

CBT-enhanced Response

Psilocybin-assisted cognitive behavioral therapy paired 10 mg and 25 mg doses with 12 CBT sessions over four months in 16 adults with major depressive disorder, with 100% retention and no serious adverse events. By treatment end, 81% (13 of 16) showed at least 25% symptom improvement and 56% (9 of 16) reached full remission, with gains sustained at 3-month follow-up and large effect sizes (Hedges’ g = 1.9–2.7). The structure appears to translate psychedelic insight into durable mood change by anchoring it to skills around emotion regulation and thinking patterns.

Psilocybin-assisted cognitive behavioral therapy paired 10 mg and 25 mg doses with 12 CBT sessions over four months in 16 adults with major depressive disorder, with 100% retention and no serious adverse events. By treatment end, 81% (13 of 16) showed at least 25% symptom improvement and 56% (9 of 16) reached full remission, with gains sustained at 3-month follow-up and large effect sizes (Hedges’ g = 1.9–2.7). The structure appears to translate psychedelic insight into durable mood change by anchoring it to skills around emotion regulation and thinking patterns.

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