Skin & Aging

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Study

Psilocybin Protected Skin Cells From Sugar-Driven Aging in Lab

Psilocybin Protected Skin Cells From Sugar-Driven Aging in Lab

Psilocybin mushrooms

What they found

Psilocybin improved survival and reduced aging markers in human skin fibroblasts exposed to high sugar and fat.

Psilocybin improved survival and reduced aging markers in human skin fibroblasts exposed to high sugar and fat.

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Biochemistry and Cell Biology

Biochemistry and Cell Biology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Skin Defense

Skin Defense

Psilocybin helped protect human skin fibroblasts (BJ5Ta) from accelerated aging triggered by high sugar and fat exposure. Treated cells showed higher survival rates, reduced oxidative stress, and lower markers of senescence, including decreased SA-β-gal activity and lower expression of p21 and p16. Psilocybin also boosted antioxidant enzyme activity and improved mitochondrial health.

Psilocybin helped protect human skin fibroblasts (BJ5Ta) from accelerated aging triggered by high sugar and fat exposure. Treated cells showed higher survival rates, reduced oxidative stress, and lower markers of senescence, including decreased SA-β-gal activity and lower expression of p21 and p16. Psilocybin also boosted antioxidant enzyme activity and improved mitochondrial health.

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