In this secondary analysis of a randomized depression trial, both psilocybin and the SSRI escitalopram reduced negative emotional bias, but they did so in different ways. Psilocybin produced a more rapid, pronounced shift away from interpreting faces and emotional cues negatively, a pattern researchers think may help explain its fast-acting antidepressant effects. Escitalopram improved bias more gradually. Overall, the findings show that while both treatments help soften the harsh, negative filtering common in depression, psilocybin may work through distinct emotional-processing pathways that support quicker psychological relief.