Mood & Mental Health

·

Study

Psilocybin Reduced Aggression in Fish

Psilocybin Reduced Aggression in Fish

Psilocybin mushrooms

What they found

Psilocybin in the water reduced movement and aggressive bursts in mangrove rivulus fish.

Psilocybin in the water reduced movement and aggressive bursts in mangrove rivulus fish.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Kryptolebias marmoratus

Kryptolebias marmoratus

Compound

psilocybin, psilocin

psilocybin, psilocin

Sample size

16 fish per treatment group

16 fish per treatment group

Published in

Frontiers in Behavioral Neuroscience

Frontiers in Behavioral Neuroscience

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Aggression Drop

Aggression Drop

Psilocybin given through water immersion at 3,000 µg/L for 20 minutes significantly reduced movement and aggressive swimming bursts in mangrove rivulus fish (Kryptolebias marmoratus), with 16 fish per treatment group. Treated fish moved less than controls with a large effect size and showed fewer aggressive bursts with a medium effect size, while whole-body psilocin levels reached about 7 ng/mL, near the 11 ng/mL peak reported after a low-to-moderate human dose. This is a weird but useful model story because it shows psilocybin calming social aggression in a naturally aggressive, self-fertilizing fish.

Psilocybin given through water immersion at 3,000 µg/L for 20 minutes significantly reduced movement and aggressive swimming bursts in mangrove rivulus fish (Kryptolebias marmoratus), with 16 fish per treatment group. Treated fish moved less than controls with a large effect size and showed fewer aggressive bursts with a medium effect size, while whole-body psilocin levels reached about 7 ng/mL, near the 11 ng/mL peak reported after a low-to-moderate human dose. This is a weird but useful model story because it shows psilocybin calming social aggression in a naturally aggressive, self-fertilizing fish.

Shroom Scan #118: Swiss psilocybin therapy, brain inflammation brakes, and mushroom leather

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