Addiction

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Study

Psilocybin Reduced Cocaine Seeking in Rats but Not Relapse

Psilocybin Reduced Cocaine Seeking in Rats but Not Relapse

Psilocybin mushrooms

What they found

Two psilocybin doses reduced cocaine lever-pressing in rats, but seeking returned when drug cues came back.

Two psilocybin doses reduced cocaine lever-pressing in rats, but seeking returned when drug cues came back.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Addiction Biology

Addiction Biology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Cocaine-Seeking Drop

Cocaine-Seeking Drop

Psilocybin helped animals stop cocaine-seeking behavior faster during recovery training. In rats trained to self-administer cocaine (0.25–0.5 mg/kg per infusion), two psilocybin doses (1.25 mg/kg then 5 mg/kg) significantly reduced lever-pressing for cocaine one day after the second dose. However, when drug-associated cues returned, cocaine-seeking behavior came back, showing the treatment did not significantly prevent relapse.

Psilocybin helped animals stop cocaine-seeking behavior faster during recovery training. In rats trained to self-administer cocaine (0.25–0.5 mg/kg per infusion), two psilocybin doses (1.25 mg/kg then 5 mg/kg) significantly reduced lever-pressing for cocaine one day after the second dose. However, when drug-associated cues returned, cocaine-seeking behavior came back, showing the treatment did not significantly prevent relapse.

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