Mood & Mental Health

·

Review

Psilocybin Reduces Depression Across Nine Trials, but Questions Remain

Psilocybin Reduces Depression Across Nine Trials, but Questions Remain

Psilocybin mushrooms

What they found

Across 9 trials with 602 people, psilocybin reduced depression, though smaller lower-quality studies showed bigger effects.

Across 9 trials with 602 people, psilocybin reduced depression, though smaller lower-quality studies showed bigger effects.

The number

9 trials with 602 participants

How solid is it?

Strong human

Strong human

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

602 participants

602 participants

Published in

Psychopharmacology

Psychopharmacology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Questions Remain

Questions Remain

Across 9 trials with 602 participants, psilocybin significantly reduced depression symptoms. But smaller, lower-quality studies showed stronger effects, and most didn’t clearly report harms or explain how it works.

Across 9 trials with 602 participants, psilocybin significantly reduced depression symptoms. But smaller, lower-quality studies showed stronger effects, and most didn’t clearly report harms or explain how it works.

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