Mood & Mental Health

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Study

Psilocybin-Related Drug RE104 Promising for Postpartum Depression

Psilocybin-Related Drug RE104 Promising for Postpartum Depression

Psilocybin mushrooms

What they found

RE104, a shorter-acting psilocybin-related prodrug, showed promising phase 1 results and moves to a phase 2 trial for postpartum depression.

RE104, a shorter-acting psilocybin-related prodrug, showed promising phase 1 results and moves to a phase 2 trial for postpartum depression.

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

RE104

RE104

Published in

Psychiatric Times

Psychiatric Times

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Postpartum Depression

Postpartum Depression

RE104, a novel psychedelic prodrug related to psilocybin, has shown promising results in a phase 1 trial targeting postpartum depression (PPD). RE104 converts in the body to an active drug metabolite that influences serotonin receptors, like psilocybin, but is designed to have a shorter psychoactive effect to make the treatment more manageable. With the upcoming phase 2 RECONNECT trial, RE104 will be administered as a single dose to women with PPD, with the goal of significantly improving their quality of life.

RE104, a novel psychedelic prodrug related to psilocybin, has shown promising results in a phase 1 trial targeting postpartum depression (PPD). RE104 converts in the body to an active drug metabolite that influences serotonin receptors, like psilocybin, but is designed to have a shorter psychoactive effect to make the treatment more manageable. With the upcoming phase 2 RECONNECT trial, RE104 will be administered as a single dose to women with PPD, with the goal of significantly improving their quality of life.

Psilocybin for Postpartum Depression, Rare Truffle Find, and Mushroom Festivals Near You

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