Safety & Toxicity

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Study

Psilocybin's Rough Come-Up Often Gives Way to Peaceful Come-Down

Psilocybin's Rough Come-Up Often Gives Way to Peaceful Come-Down

Psilocybin mushrooms

What they found

During the come-up 34% report nausea and 28% anxiety, while the come-down brings pleasant and peaceful states.

During the come-up 34% report nausea and 28% anxiety, while the come-down brings pleasant and peaceful states.

The number

34% of users report nausea

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

npj Mental Health Research

npj Mental Health Research

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Ups and Downs

Ups and Downs

During the come-up, 34% of users report nausea, 28% feel anxiety, and 21% experience restlessness—an acute stress response that may aid therapeutic breakthroughs. The come-down brings a shift to positive states, with 34% feeling pleasant, 22% peaceful, and 17% reflective. This emotional transition could be key to psilocybin’s healing effects.

During the come-up, 34% of users report nausea, 28% feel anxiety, and 21% experience restlessness—an acute stress response that may aid therapeutic breakthroughs. The come-down brings a shift to positive states, with 34% feeling pleasant, 22% peaceful, and 17% reflective. This emotional transition could be key to psilocybin’s healing effects.

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