Mood & Mental Health

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Study

Psilocybin Strengthens Emotion-Regulating Brain Connections in Depression

Psilocybin Strengthens Emotion-Regulating Brain Connections in Depression

Psilocybin mushrooms

What they found

One psilocybin session increased amygdala–prefrontal connectivity in people with major depression.

One psilocybin session increased amygdala–prefrontal connectivity in people with major depression.

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

ojs.kaunokolegija.lt

ojs.kaunokolegija.lt

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Emotional Processing

Emotional Processing

Researchers used fMRI scans to observe how psilocybin changes the way the brain reacts to emotional conflict. In people with major depression, psilocybin increased connectivity between the amygdala and prefrontal cortex—areas tied to emotion regulation—after just one session. This shift may help explain how psilocybin reduces rumination and boosts emotional flexibility, laying the groundwork for deeper therapeutic change.

Researchers used fMRI scans to observe how psilocybin changes the way the brain reacts to emotional conflict. In people with major depression, psilocybin increased connectivity between the amygdala and prefrontal cortex—areas tied to emotion regulation—after just one session. This shift may help explain how psilocybin reduces rumination and boosts emotional flexibility, laying the groundwork for deeper therapeutic change.

Lion’s Mane vs. Microplastics, Psilocybin Self-Kindness, and Smart Packaging

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