A review of 16 studies found that psilocybin-assisted therapy led to major reductions in alcohol and tobacco use. In alcohol use disorder, participants had fewer heavy drinking days and higher abstinence rates; in tobacco studies, smoking cessation rates were as high as 80%. Mystical experiences during treatment were strong predictors of long-term success. Evidence for other addictions like opioids and cocaine was mixed, but early results were notable when psilocybin was paired with therapy.