Immunity & Infection

·

Study

Psilocybin Therapy Eased Chronic Lyme Symptoms 40%

Psilocybin Therapy Eased Chronic Lyme Symptoms 40%

Psilocybin mushrooms

What they found

In a pilot of 20 people with chronic post-treatment Lyme disease, two psilocybin sessions cut symptom burden 40% at 6 months.

In a pilot of 20 people with chronic post-treatment Lyme disease, two psilocybin sessions cut symptom burden 40% at 6 months.

The number

Overall Lyme symptom burden dropped 40% at 6 months

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

20 participants

20 participants

Published in

Scientific Reports

Scientific Reports

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Lyme Relief

Lyme Relief

People with chronic post-treatment Lyme disease often struggle with long-lasting fatigue, pain, brain fog, and depression, and this pilot trial found meaningful symptom improvements lasting up to 6 months after psilocybin therapy. In an 8-week open-label study of 20 participants, patients received two psilocybin sessions (15 mg followed by 15–25 mg) with psychological support. Overall Lyme symptom burden dropped 40% at 6 months, while quality-of-life scores improved 13%, with significant improvements also seen in mood, fatigue, sleep, and pain.

People with chronic post-treatment Lyme disease often struggle with long-lasting fatigue, pain, brain fog, and depression, and this pilot trial found meaningful symptom improvements lasting up to 6 months after psilocybin therapy. In an 8-week open-label study of 20 participants, patients received two psilocybin sessions (15 mg followed by 15–25 mg) with psychological support. Overall Lyme symptom burden dropped 40% at 6 months, while quality-of-life scores improved 13%, with significant improvements also seen in mood, fatigue, sleep, and pain.

Psilocybin Cuts Lyme Symptoms 40%, FDA Clears PTSD Trial, and Mushrooms Target Breast Cancer

Read the original study ↗

Get Shroom Scan

Next study

FDA Clears Large Psilocybin Trial for PTSD ›

Shroom Scan · Every Friday

Get Studies Like This, Translated, Every Week

Ten new studies a week, each boiled down to what it found and why it matters to you. Free, and one click to leave.

See what's inside →