Mood & Mental Health

·

Study

Psilocybin Therapy Eased Depression in COVID Frontline Health Workers

Psilocybin Therapy Eased Depression in COVID Frontline Health Workers

Psilocybin mushrooms

What they found

In a randomized trial of 30 frontline clinicians, 25mg psilocybin cut depression scores by 21.33 points versus 9.33 with placebo.

In a randomized trial of 30 frontline clinicians, 25mg psilocybin cut depression scores by 21.33 points versus 9.33 with placebo.

The number

-21.33 vs -9.33 point reductions in MADRS scores

How solid is it?

Early human

Early human

Human – RCT

Human – RCT

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

30 participants

30 participants

Published in

JAMA Network

JAMA Network

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Frontline Healthcare Workers

Frontline Healthcare Workers

A groundbreaking JAMA Network Open trial found that psilocybin therapy (25mg) significantly reduced depression in COVID-19 frontline healthcare workers, with treatment groups showing -21.33 vs -9.33 point reductions in MADRS scores. The randomized study of 30 participants demonstrated sustained improvements through 6-month follow-up. Though 70% of participants modified their work roles during the study period, none left healthcare.

A groundbreaking JAMA Network Open trial found that psilocybin therapy (25mg) significantly reduced depression in COVID-19 frontline healthcare workers, with treatment groups showing -21.33 vs -9.33 point reductions in MADRS scores. The randomized study of 30 participants demonstrated sustained improvements through 6-month follow-up. Though 70% of participants modified their work roles during the study period, none left healthcare.

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