A groundbreaking preprint study testing psilocybin-assisted therapy in fibromyalgia patients showed promising early results, with three participants reporting significant improvement in symptoms. The therapy, combining two doses of psilocybin (15mg and 25mg) with supportive psychotherapy, demonstrated notable reductions in pain severity, sleep disturbance, and anxiety levels and was safe, with only minor transient effects like headaches reported. While these preliminary results from this small, uncontrolled trial are encouraging, three larger clinical trials are currently underway to better understand psilocybin's potential in treating fibromyalgia - a condition affecting 2-4% of the population that is difficult to treat.