In people with methamphetamine use disorder, psilocybin-assisted therapy was linked to measurable changes in brain networks tied to attention, self-reflection, salience, and cognitive control. Brain scans showed stronger network organization after treatment, with local activity shifts in frontal and sensorimotor regions. Greater reductions in meth use tracked with recovery in frontostriatal and attention circuits, making this a strong early signal for psilocybin’s role in addiction and brain plasticity research.