In a small open-label pilot study of 5 adults with binge eating disorder, a single 25 mg dose of psilocybin paired with therapy was well tolerated, with no serious adverse events reported. All participants showed reductions in binge eating frequency that persisted through 14 weeks, alongside improvements in depression, anxiety, and psychological flexibility, and 3 of 5 participants also saw reductions in BMI and waist circumference. While preliminary and not causal, the results suggest that psilocybin-assisted therapy may help interrupt compulsive eating patterns by increasing cognitive and emotional flexibility.