Psilocybin-assisted psychotherapy (Psilocybe spp.) helped people feel interest, enjoyment, and reward again, even when standard antidepressants had failed. The results saw reduced anhedonia scores by an average of 3.1 points on the SHAPS scale at 2 weeks in people with treatment-resistant depression, with clinically meaningful improvements lasting 3–6 months. 90% of participants started with significant emotional numbness, and reductions in anhedonia occurred partly independent of overall depression score changes, showing a distinct effect on pleasure and motivation.