Law & Policy

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Review

Psilocybin Therapy Works but Is Costly to Scale

Psilocybin Therapy Works but Is Costly to Scale

Psilocybin mushrooms

What they found

An analysis of real-world psilocybin therapy notes depression scores dropped 6.6 points at 3 weeks, but one-to-one staffing makes it costly.

An analysis of real-world psilocybin therapy notes depression scores dropped 6.6 points at 3 weeks, but one-to-one staffing makes it costly.

The number

−6.6 points at 3 weeks

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Cambridge University Press

Cambridge University Press

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Real-World Therapy Model

Real-World Therapy Model

Psilocybin therapy uses single doses around 25 mg with 6–8 hour guided sessions, requiring continuous clinical support before, during, and after treatment. Trials show depression score reductions of −6.6 points at 3 weeks and ~−3.6 to −3.8 at 6 weeks, but the one-to-one staffing model creates major cost and scalability challenges.

Psilocybin therapy uses single doses around 25 mg with 6–8 hour guided sessions, requiring continuous clinical support before, during, and after treatment. Trials show depression score reductions of −6.6 points at 3 weeks and ~−3.6 to −3.8 at 6 weeks, but the one-to-one staffing model creates major cost and scalability challenges.

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