Mood & Mental Health

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Study

Psilocybin Trial in Treatment-Resistant Depression Shows Early Benefit

Psilocybin Trial in Treatment-Resistant Depression Shows Early Benefit

Psilocybin mushrooms

What they found

In 144 treatment-resistant patients, 25 mg psilocybin cut depression scores 4.60 points versus placebo, with 34.0% responding at week 1.

In 144 treatment-resistant patients, 25 mg psilocybin cut depression scores 4.60 points versus placebo, with 34.0% responding at week 1.

The number

response rates reaching 34.0% at week 1 vs 6.4% in controls

How solid is it?

Early human

Early human

Human – RCT

Human – RCT

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

144 treatment-resistant patients

144 treatment-resistant patients

Published in

JAMA Network

JAMA Network

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Depression Reduction Signal

Depression Reduction Signal

Psilocybin (25 mg) in 144 treatment-resistant patients reduced depression scores by −4.60 points vs placebo on HAMD17 (p < 0.001), with response rates reaching 34.0% at week 1 vs 6.4% in controls. By week 6, symptom improvement remained stronger (−3.68 average change), though primary response rates were not statistically significant (17.0% vs 10.6%). Adverse events occurred in 100% of high-dose sessions, including ~4% suicidal ideation and 2 serious cases, reinforcing the need for supervised use.

Psilocybin (25 mg) in 144 treatment-resistant patients reduced depression scores by −4.60 points vs placebo on HAMD17 (p < 0.001), with response rates reaching 34.0% at week 1 vs 6.4% in controls. By week 6, symptom improvement remained stronger (−3.68 average change), though primary response rates were not statistically significant (17.0% vs 10.6%). Adverse events occurred in 100% of high-dose sessions, including ~4% suicidal ideation and 2 serious cases, reinforcing the need for supervised use.

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