Psychedelic-assisted couples therapy is being explored as a new way to treat addiction and codependency together, rather than in isolation. This review outlines a paired approach where psilocybin is used to help individuals with substance use disorders reduce cravings, loosen rigid behavior patterns, and reconnect with meaning, while MDMA is used to support partners by increasing empathy, trust, and emotional safety during therapy. By combining individual psychedelic sessions with structured couples integration, the model aims to repair relationship dynamics that often fuel relapse, positioning psychedelic-assisted couples therapy as a promising next frontier for addiction and relational healing.