A systematic review examined how different psychedelics influence brain plasticity and neurogenesis—the process of forming new neurons. Researchers analyzed studies on classical psychedelics like psilocybin, LSD, and DMT, as well as cannabinoids and NMDA antagonists like ketamine. Findings suggest that psychedelics enhance brain growth and adaptability by stimulating neurotrophic factors like BDNF, which supports synaptic connections. This could explain their rapid antidepressant effects and potential for treating mood disorders.