Safety & Toxicity

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Review

Psychedelics Dip Memory Briefly but Show No Lasting Harm

Psychedelics Dip Memory Briefly but Show No Lasting Harm

Psilocybin mushrooms

What they found

A review found attention and working memory drop during and up to 24 hours after a trip, with no lasting harm.

A review found attention and working memory drop during and up to 24 hours after a trip, with no lasting harm.

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Current Topics in Behavioral Neurosciences

Current Topics in Behavioral Neurosciences

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Memory Loss

Memory Loss

A comparative review of psilocybin, LSD, and ayahuasca found that while attention and working memory drop temporarily during a trip—and sometimes up to 24 hours afterward—there are no signs of lasting neuropsychological harm. Among the classic psychedelics, psilocybin showed the most favorable profile, with fewer acute drawbacks and stronger promise for safe, long-term mental health applications.

A comparative review of psilocybin, LSD, and ayahuasca found that while attention and working memory drop temporarily during a trip—and sometimes up to 24 hours afterward—there are no signs of lasting neuropsychological harm. Among the classic psychedelics, psilocybin showed the most favorable profile, with fewer acute drawbacks and stronger promise for safe, long-term mental health applications.

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