In a mixed-methods study of 19 people using reishi (Ganoderma lucidum) and lion’s mane (Hericium erinaceus) for epilepsy, 68.4% reported reductions in both seizure frequency and severity, and 11/19 (57.9%) described periods of seizure freedom; among those with drug-resistant epilepsy (n=14), 42.1% reported major severity reductions and 36.8% saw major frequency drops. Only one mild GI side effect was reported; dosing remains non-standardized, and the authors call for controlled trials to confirm efficacy and define protocols.