Researchers found that reishi (Ganoderma lucidum) can be successfully cultivated on a wide range of agricultural and wood-based waste, like oak sawdust, hazelnut husks, wheat straw, and even spent coffee grounds. Oak wood mixed with wheat bran produced the highest yield (46 g/kg), while corn husk and wheat straw yielded the least. Chemical analysis showed that reishi actively breaks down complex fibers in the substrate, making this a promising, low-cost method for sustainable cultivation.