Over 40% of the world’s population has some form of a gastrointestinal disorder, but it’s still hard to find effective treatments. Holistic practitioners often turn patients to medicinal mushrooms like chaga, lion’s mane, and turkey tail, and in the last ten years, more clinical research applying medicinal mushrooms to GI disorders has been published. Recently, researchers in Romania conducted an in-depth literature review on the topic of medicinal mushrooms and gastric conditions. Such reviews are crucial for emerging fields, sifting through numerous studies to identify key trends and guide research funding and efforts. This review refined its focus from 61 to 7 studies that specifically explored the relationship between medicinal mushrooms and gastric conditions. All sevens studies showed positive effects of mushrooms on GI disorders. The catch is that the seven studies focused on animals, not humans. This isn’t uncommon in the world of medicine as clinical research, especially, is at the hands of time. Medicinal mushrooms have high levels of gastroprotective effects due to their bioactive compounds like polysachharides and beta-glucans, which, in turn, create high levels of anxtioxidants that bolster and regulate our digestive tract. Higher doses of mushroom extracts led to significant improvements in gastric ulcers. This suggests that dosage is important for achieving the best therapeutic outcomes, something for future studies to explore in research on human subjects.