Mood & Mental Health

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Review

Review Summarizes Psilocybin Macrodosing vs Microdosing

Review Summarizes Psilocybin Macrodosing vs Microdosing

Psilocybin mushrooms

What they found

A 2025 review summarizes psilocybin macrodoses (≈3–5 g dried) and microdoses (≈0.1–0.5 g), with microdosing results still mixed.

A 2025 review summarizes psilocybin macrodoses (≈3–5 g dried) and microdoses (≈0.1–0.5 g), with microdosing results still mixed.

The number

≈3–5 g dried Psilocybe

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Psilocybe

Psilocybe

Compound

psilocybin

psilocybin

Published in

revistas.unc.edu.ar

revistas.unc.edu.ar

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Dose Spectrum

Dose Spectrum

A 2025 review summarizes therapeutic uses of psilocybin across macrodosing (≈3–5 g dried Psilocybe or 20–30 mg synthetic) and microdosing (≈0.1–0.5 g dried or 0.8–5 mg), noting brain-network effects (DMN modulation, increased global integration) linked with mood improvements in trials, and generally good tolerability in controlled settings with psychotherapy. Evidence for pain conditions is emerging (e.g., migraine/cluster-headache pulse regimens) while microdosing results remain mixed and preliminary.

A 2025 review summarizes therapeutic uses of psilocybin across macrodosing (≈3–5 g dried Psilocybe or 20–30 mg synthetic) and microdosing (≈0.1–0.5 g dried or 0.8–5 mg), noting brain-network effects (DMN modulation, increased global integration) linked with mood improvements in trials, and generally good tolerability in controlled settings with psychotherapy. Evidence for pain conditions is emerging (e.g., migraine/cluster-headache pulse regimens) while microdosing results remain mixed and preliminary.

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