Brain & Cognition

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Study

Shiitake Extract Recharges Energy in Aging Brain Cells

Shiitake Extract Recharges Energy in Aging Brain Cells

Shiitake

What they found

Ergothioneine-rich shiitake extract gave aging brain cells 136% more energy production than untreated cells.

Ergothioneine-rich shiitake extract gave aging brain cells 136% more energy production than untreated cells.

The number

70.5% higher membrane potential and 136% more energy production

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Lentinula edodes

Lentinula edodes

Compound

ergothioneine

ergothioneine

Published in

Neuroscience

Neuroscience

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Brain Boost

Brain Boost

Ergothioneine-rich shiitake mushroom extract (Lentinula edodes) was found to restore mitochondrial function in aging brain cells, with treated cells showing 70.5% higher membrane potential and 136% more energy production compared to untreated cells. The extract protected neurons through multiple pathways, increasing protective antioxidant genes by 121% and reducing inflammation markers by over 50%.

Ergothioneine-rich shiitake mushroom extract (Lentinula edodes) was found to restore mitochondrial function in aging brain cells, with treated cells showing 70.5% higher membrane potential and 136% more energy production compared to untreated cells. The extract protected neurons through multiple pathways, increasing protective antioxidant genes by 121% and reducing inflammation markers by over 50%.

🧠 Reishi’s Liver Shield, Shiitake’s Brain Boost, and a Trip to China

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