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Study

Shiitake Stem Extract Reverses Bone Loss in Zebrafish

Shiitake Stem Extract Reverses Bone Loss in Zebrafish

Shiitake

What they found

Shiitake stem extracts reduced bone-breakdown cells in the lab and restored bone mineralization in zebrafish.

Shiitake stem extracts reduced bone-breakdown cells in the lab and restored bone mineralization in zebrafish.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Lentinula edodes

Lentinula edodes

Published in

www.jbtr.or.kr

www.jbtr.or.kr

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Stronger Bones

Stronger Bones

Shiitake mushroom (Lentinula edodes) stipe extracts, regardless of drying method, significantly reduced osteoclast formation in vitro by suppressing a key regulator of bone breakdown. In an osteoporosis-induced zebrafish model, hot-air dried stipe extract restored bone mineralization and reversed steroid-induced bone loss.

Shiitake mushroom (Lentinula edodes) stipe extracts, regardless of drying method, significantly reduced osteoclast formation in vitro by suppressing a key regulator of bone breakdown. In an osteoporosis-induced zebrafish model, hot-air dried stipe extract restored bone mineralization and reversed steroid-induced bone loss.

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