Pain & Headache

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Study

Single Psilocybin Dose Cuts Phantom Limb Pain by 59%

Single Psilocybin Dose Cuts Phantom Limb Pain by 59%

Psilocybin mushrooms

What they found

One 25 mg psilocybin dose reduced phantom limb pain by 59% and residual limb pain by nearly 80% for at least 4 weeks.

One 25 mg psilocybin dose reduced phantom limb pain by 59% and residual limb pain by nearly 80% for at least 4 weeks.

The number

reduced phantom limb pain by 59%

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Phantom Pain Relief

Phantom Pain Relief

A single 25 mg dose of psilocybin reduced phantom limb pain by 59% and residual limb pain by nearly 80% in amputees, with effects lasting at least 4 weeks. No serious side effects were reported. Researchers believe psilocybin helps “reset” pain signals in the brain by activating pathways involved in emotion and perception.

A single 25 mg dose of psilocybin reduced phantom limb pain by 59% and residual limb pain by nearly 80% in amputees, with effects lasting at least 4 weeks. No serious side effects were reported. Researchers believe psilocybin helps “reset” pain signals in the brain by activating pathways involved in emotion and perception.

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