Mood & Mental Health

·

Study

Single Psilocybin Dose Eased Body Dysmorphic Disorder Symptoms

Single Psilocybin Dose Eased Body Dysmorphic Disorder Symptoms

Psilocybin mushrooms

What they found

In 8 adults with body dysmorphic disorder, one 25 mg psilocybin dose cut symptoms within a week, lasting 12 weeks.

In 8 adults with body dysmorphic disorder, one 25 mg psilocybin dose cut symptoms within a week, lasting 12 weeks.

The number

predicted a 73% reduction in symptoms

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

8 adults

8 adults

Published in

Psychedelics (Genomic Press)

Psychedelics (Genomic Press)

Covered in Shroom Scan

Section

CATEGORY OF STORY

CATEGORY OF STORY

As it ran in Shroom Scan

The Effect of Single-Dose Psilocybin on Body Dysmorphic Disorder

The Effect of Single-Dose Psilocybin on Body Dysmorphic Disorder

Scientists gave a single dose of psilocybin (25 mg) to 8 adults struggling with body dysmorphic disorder (BDD), a condition where people obsess over perceived flaws in their appearance. Brain scans were done before and one day after taking the drug. Amazingly, BDD symptoms dropped significantly just one week later and stayed lower even after 12 weeks. The brain scans revealed some interesting changes. One day after taking psilocybin, there was more communication between brain areas responsible for: Focusing attention and controlling thoughts (Executive Control Network) Self-reflection and mind-wandering (Default Mode Network) Detecting important information (Salience Network) The more these brain areas "talked" to each other, the more people's BDD symptoms improved. For example, increased connectivity between the dorsolateral prefrontal cortex and superior parietal lobule predicted a 73% reduction in symptoms. This early study suggests psilocybin might help people with BDD by allowing different parts of their brain to work together better, potentially making it easier to shift attention away from appearance concerns and regulate emotions. However, with only 8 participants and no control group, larger studies are needed to confirm these promising results.

Scientists gave a single dose of psilocybin (25 mg) to 8 adults struggling with body dysmorphic disorder (BDD), a condition where people obsess over perceived flaws in their appearance. Brain scans were done before and one day after taking the drug. Amazingly, BDD symptoms dropped significantly just one week later and stayed lower even after 12 weeks. The brain scans revealed some interesting changes. One day after taking psilocybin, there was more communication between brain areas responsible for: Focusing attention and controlling thoughts (Executive Control Network) Self-reflection and mind-wandering (Default Mode Network) Detecting important information (Salience Network) The more these brain areas "talked" to each other, the more people's BDD symptoms improved. For example, increased connectivity between the dorsolateral prefrontal cortex and superior parietal lobule predicted a 73% reduction in symptoms. This early study suggests psilocybin might help people with BDD by allowing different parts of their brain to work together better, potentially making it easier to shift attention away from appearance concerns and regulate emotions. However, with only 8 participants and no control group, larger studies are needed to confirm these promising results.

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