Mood & Mental Health

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Study

Single Psilocybin Dose Eased Chronic Suicidal Thoughts

Single Psilocybin Dose Eased Chronic Suicidal Thoughts

Psilocybin mushrooms

What they found

Twenty adults with chronic suicidal thoughts had scores drop nearly 14 points after one psilocybin session, and 70% had minimal or no suicidal thoughts by the end.

Twenty adults with chronic suicidal thoughts had scores drop nearly 14 points after one psilocybin session, and 70% had minimal or no suicidal thoughts by the end.

The number

70% of participants reported minimal or no suicidal thoughts

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

Twenty adults

Twenty adults

Published in

The Journal of Clinical Psychiatry

The Journal of Clinical Psychiatry

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Hope After Years

Hope After Years

Twenty adults with chronic suicidal thoughts and at least two prior antidepressant treatment failures received a single 25 mg psilocybin session, with suicidal-thinking scores dropping by nearly 14 points after 3 weeks. Improvements appeared within 1 week, remained significant through 12 weeks, and 70% of participants reported minimal or no suicidal thoughts by the end of follow-up. No serious adverse events were reported.

Twenty adults with chronic suicidal thoughts and at least two prior antidepressant treatment failures received a single 25 mg psilocybin session, with suicidal-thinking scores dropping by nearly 14 points after 3 weeks. Improvements appeared within 1 week, remained significant through 12 weeks, and 70% of participants reported minimal or no suicidal thoughts by the end of follow-up. No serious adverse events were reported.

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