Safety & Toxicity

·

Study

Some Medications May Intensify Psilocybin's Effects

Some Medications May Intensify Psilocybin's Effects

Psilocybin mushrooms

What they found

In animals, carbamazepine, which affects CYP450 enzymes, increased psilocybin's impact, raising safety concerns for people on psychiatric meds.

In animals, carbamazepine, which affects CYP450 enzymes, increased psilocybin's impact, raising safety concerns for people on psychiatric meds.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin; carbamazepine

psilocybin; carbamazepine

Published in

jpet.aspetjournals.org

jpet.aspetjournals.org

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Medication Mix Caution

Medication Mix Caution

Psilocybin's effects may intensify when taken with drugs like carbamazepine, which influence CYP450 enzymes that metabolize psilocybin. In animal models, combining the two shifted how psilocybin worked in the brain and increased its impact, raising safety concerns for people on antidepressants, antiepileptics, or other psychiatric meds.

Psilocybin's effects may intensify when taken with drugs like carbamazepine, which influence CYP450 enzymes that metabolize psilocybin. In animal models, combining the two shifted how psilocybin worked in the brain and increased its impact, raising safety concerns for people on antidepressants, antiepileptics, or other psychiatric meds.

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