Immunity & Infection

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Study

Special Shiitake Strain Reduces Swelling in Rats

Special Shiitake Strain Reduces Swelling in Rats

Shiitake

What they found

Shiitake strain DMRO-356 reduced swelling in rats by 22% versus 7% for a comparison strain.

Shiitake strain DMRO-356 reduced swelling in rats by 22% versus 7% for a comparison strain.

The number

reduced swelling by 22% (vs just 7% in a comparison strain)

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Lentinula edodes

Lentinula edodes

Compound

β-glucans, ergosterol, ergothioneine

β-glucans, ergosterol, ergothioneine

Published in

Journal of Ethnopharmacology

Journal of Ethnopharmacology

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Shiitake vs Inflammation

Shiitake vs Inflammation

A special shiitake strain (Lentinula edodes DMRO-356) showed strong anti-inflammatory activity compared to other strains. In rats, it reduced swelling by 22% (vs just 7% in a comparison strain) and contained higher levels of β-glucans, ergosterol, and ergothioneine. Molecular docking confirmed these compounds stably bound to inflammatory targets.

A special shiitake strain (Lentinula edodes DMRO-356) showed strong anti-inflammatory activity compared to other strains. In rats, it reduced swelling by 22% (vs just 7% in a comparison strain) and contained higher levels of β-glucans, ergosterol, and ergothioneine. Molecular docking confirmed these compounds stably bound to inflammatory targets.

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