Safety & Toxicity

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Study

SSRI Antidepressants Can Dull Psilocybin Effects

SSRI Antidepressants Can Dull Psilocybin Effects

Psilocybin mushrooms

What they found

In mice, fluoxetine reduced responses to psychedelics including psilocybin, with responsiveness returning 14 days after stopping.

In mice, fluoxetine reduced responses to psychedelics including psilocybin, with responsiveness returning 14 days after stopping.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

fluoxetine, psilocybin, DOI

fluoxetine, psilocybin, DOI

Published in

ACS Pharmacology & Translational Science

ACS Pharmacology & Translational Science

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

SSRI Interference Effect

SSRI Interference Effect

Fluoxetine (SSRI) at 10 mg/kg reduced psychedelic response in mice after 14 days of use, lowering sensitivity to compounds like DOI by shifting the dose-response curve downward. Acute fluoxetine also reduced psilocybin’s behavioral impact without changing its potency, showing immediate interference with effects. After stopping fluoxetine for 14 days, psychedelic responsiveness returned, indicating timing of SSRI use directly changes therapeutic outcomes.

Fluoxetine (SSRI) at 10 mg/kg reduced psychedelic response in mice after 14 days of use, lowering sensitivity to compounds like DOI by shifting the dose-response curve downward. Acute fluoxetine also reduced psilocybin’s behavioral impact without changing its potency, showing immediate interference with effects. After stopping fluoxetine for 14 days, psychedelic responsiveness returned, indicating timing of SSRI use directly changes therapeutic outcomes.

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