Brain & Cognition

·

Review

The 5-HT2A Receptor Is Key to Psilocybin's Effects

The 5-HT2A Receptor Is Key to Psilocybin's Effects

Psilocybin mushrooms

What they found

A review explains how activating the 5-HT2A receptor drives psilocybin's effects on plasticity and depression.

A review explains how activating the 5-HT2A receptor drives psilocybin's effects on plasticity and depression.

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Journal of Medicinal Chemistry

Journal of Medicinal Chemistry

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Serotonin Switchboard

Serotonin Switchboard

The 5-HT2A receptor is the key target of psilocybin and other classic psychedelics, driving their effects on mood, perception, and cognition. This review breaks down how activating this receptor enhances brain plasticity, reduces depressive symptoms, and reshapes rigid thought patterns.

The 5-HT2A receptor is the key target of psilocybin and other classic psychedelics, driving their effects on mood, perception, and cognition. This review breaks down how activating this receptor enhances brain plasticity, reduces depressive symptoms, and reshapes rigid thought patterns.

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