Two traditional mushrooms from Mexico—blue Lactarius indigo and red Amanita jacksonii—show strong nutraceutical potential. L. indigo contained high levels of protocatechuic acid that lowered cholesterol enzymes and protected mice on high-calorie diets. A. jacksonii was rich in p-hydroxybenzoic acid, which blocked pancreatic lipase and reduced triglycerides in mice on fatty diets. Both also showed antiproliferative effects in cancer cells, linking their phenolic content to antioxidant and metabolic health benefits.