The effectiveness of five white-rot fungi species in removing the cytostatic drugs bleomycin and vincristine from wastewater was evaluated in a jaw-dropping study. These drugs often end up in wastewater through patient excretion after cancer treatments because conventional wastewater treatments are typically ineffective at breaking down these potent, chemically stable compounds, which then enter aquatic systems. Turkey tail (Trametes versicolor) and Hypholoma fasciculare were the most efficient, eliminating over 90% of vincristine in just two days, and reducing bleomycin by 55% and 83% after nine days.