Wood-decomposing fungi like turkey tail (Trametes versicolor) have shown early promise in breaking down toxic PFAS compounds, also known as “forever chemicals.” These fungi triggered defluorination activity when exposed to certain perfluorinated carboxylic acids, cleaving carbon–fluorine bonds once thought nearly unbreakable. While legacy PFAS like PFOA and PFOS proved more resistant, the fungi successfully degraded newer PFAS with electron-attracting alkenyl groups, offering a potential breakthrough in remediating some of the planet’s most persistent pollutants.