Psilocybin mushrooms (Psilocybe spp.) were modeled as multi-compound systems, with psilocybin, psilocin, β-carbolines, and other indoles collectively targeting serotonin (5-HT2A), dopamine, glutamate, and neurotrophic pathways rather than a single receptor. This helps explain why whole mushrooms can feel broader and longer-lasting than isolated psilocybin, with multiple compounds shaping mood, cognition, and emotional flexibility at once.