Brain & Cognition

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Study

Age and Hormones Change Psilocybin's Effect on Learning in Rats

Age and Hormones Change Psilocybin's Effect on Learning in Rats

Psilocybin mushrooms

What they found

Psilocybin improved cognitive flexibility in young female rats but not older ones, and learning dipped during estrus.

Psilocybin improved cognitive flexibility in young female rats but not older ones, and learning dipped during estrus.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Age and Hormones Matter

Age and Hormones Matter

Psilocybin affects learning and mental flexibility differently depending on age and hormonal cycle, at least in female rats. In this study, young adults showed improved cognitive flexibility after psilocybin, while older rats didn’t. Learning performance also dipped during the estrus phase, showing how estrogen levels might shape psychedelic outcomes.

Psilocybin affects learning and mental flexibility differently depending on age and hormonal cycle, at least in female rats. In this study, young adults showed improved cognitive flexibility after psilocybin, while older rats didn’t. Learning performance also dipped during the estrus phase, showing how estrogen levels might shape psychedelic outcomes.

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