Hormones & Reproductive

·

Study

Button Mushroom Polysaccharide Protects Sperm Cells From X-Rays

Button Mushroom Polysaccharide Protects Sperm Cells From X-Rays

Button mushroom

What they found

Button mushroom polysaccharide protected developing sperm cells from X-ray damage by activating a cell-survival pathway.

Button mushroom polysaccharide protected developing sperm cells from X-ray damage by activating a cell-survival pathway.

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Agaricus bisporus

Agaricus bisporus

Compound

polysaccharide

polysaccharide

Published in

Food & Function

Food & Function

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Radiation Shield Cells

Radiation Shield Cells

White button mushroom (Agaricus bisporus) polysaccharide protected developing sperm cells from X-ray damage by activating the PI3K/AKT/mTOR survival pathway, a core cellular repair system. Pretreatment improved cell viability, reduced oxidative stress, lowered inflammatory signals like IL-1β, IL-6, and TNF-α, suppressed pro-death genes (Caspase-3, Caspase-8, Bax), and increased the protective gene Bcl-2, effectively keeping cells alive under radiation stress.

White button mushroom (Agaricus bisporus) polysaccharide protected developing sperm cells from X-ray damage by activating the PI3K/AKT/mTOR survival pathway, a core cellular repair system. Pretreatment improved cell viability, reduced oxidative stress, lowered inflammatory signals like IL-1β, IL-6, and TNF-α, suppressed pro-death genes (Caspase-3, Caspase-8, Bax), and increased the protective gene Bcl-2, effectively keeping cells alive under radiation stress.

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