FDA Clears First U.S. Trial Using Whole Psilocybin Mushrooms

Psilocybin mushrooms

What they found

The FDA cleared the first U.S. clinical trial using whole psilocybin mushrooms for PTSD, chronic pain and opioid addiction.

The number

14 grow cycles and 40 tests

How solid is it?

n/a

Not a study

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

Published in

Phoenix New Times

Covered in Shroom Scan

Apr 11, 2025

Section

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Whole Shrooms Approved

The FDA cleared Scottsdale Research Institute to begin the first U.S. clinical trial using whole psilocybin mushrooms, specifically a strain called Jedi Mind Fuck, to treat PTSD, chronic pain, and opioid addiction. Unlike standard trials with synthetic psilocybin, this study will test full-spectrum mushrooms, standardized through 14 grow cycles and 40 tests, to evaluate the therapeutic potential of their complete compound profile.

Faster Thinking, Safer Cordyceps, and a Psilocybin Milestone

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