Immunity & Infection

·

Study

Fungal Compound Reduced Lung Inflammation in Mice

Fungal Compound Reduced Lung Inflammation in Mice

Aspergillus

What they found

Butyrolactone I from Aspergillus terreus blocked a neutrophil receptor and reduced lung injury in mice with ARDS.

Butyrolactone I from Aspergillus terreus blocked a neutrophil receptor and reduced lung injury in mice with ARDS.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Aspergillus terreus

Aspergillus terreus

Compound

butyrolactone I

butyrolactone I

Published in

Biochemical Pharmacology

Biochemical Pharmacology

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Lung Relief

Lung Relief

A natural compound called butyrolactone I, produced by Aspergillus terreus fungi, can block a receptor on immune cells (FPR1) that drives acute respiratory distress syndrome (ARDS). In human neutrophils, it shut down harmful reactions like superoxide bursts, elastase release, and excessive migration, all without being toxic. In mice with ARDS, treatment lowered lung inflammation, oxidative stress, and key damage markers while also reducing neutrophil infiltration. This suggests the fungal compound could be developed as a new therapeutic strategy for ARDS and related lung injury.

A natural compound called butyrolactone I, produced by Aspergillus terreus fungi, can block a receptor on immune cells (FPR1) that drives acute respiratory distress syndrome (ARDS). In human neutrophils, it shut down harmful reactions like superoxide bursts, elastase release, and excessive migration, all without being toxic. In mice with ARDS, treatment lowered lung inflammation, oxidative stress, and key damage markers while also reducing neutrophil infiltration. This suggests the fungal compound could be developed as a new therapeutic strategy for ARDS and related lung injury.

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