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Study

Lion's Mane Slowed Knee Arthritis Damage in Rats

Lion's Mane Slowed Knee Arthritis Damage in Rats

Lion's mane

What they found

Lion's mane mycelium at 100 mg/kg, alone or with type II collagen, reduced cartilage breakdown and joint inflammation in rats with knee arthritis.

Lion's mane mycelium at 100 mg/kg, alone or with type II collagen, reduced cartilage breakdown and joint inflammation in rats with knee arthritis.

The number

100 mg/kg of lion’s mane mycelium

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Hericium erinaceus

Hericium erinaceus

Compound

undenatured type II collagen

undenatured type II collagen

Published in

International Journal of Medical Sciences

International Journal of Medical Sciences

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Joint Damage Slowdown

Joint Damage Slowdown

Lion’s mane mushroom (Hericium erinaceus) mycelium combined with undenatured type II collagen helped slow osteoarthritis damage in rats with surgically induced knee arthritis. Animals given 100 mg/kg of lion’s mane mycelium, alone or with collagen, showed significantly less cartilage breakdown and improved bone structure compared with untreated osteoarthritis controls. The treatment also reduced inflammatory joint signals IL-1β and TNF-α and lowered cartilage-degrading enzymes such as MMP-3, MMP-13, and ADAMTS5, which are strongly linked to osteoarthritis progression.

Lion’s mane mushroom (Hericium erinaceus) mycelium combined with undenatured type II collagen helped slow osteoarthritis damage in rats with surgically induced knee arthritis. Animals given 100 mg/kg of lion’s mane mycelium, alone or with collagen, showed significantly less cartilage breakdown and improved bone structure compared with untreated osteoarthritis controls. The treatment also reduced inflammatory joint signals IL-1β and TNF-α and lowered cartilage-degrading enzymes such as MMP-3, MMP-13, and ADAMTS5, which are strongly linked to osteoarthritis progression.

Lion’s Mane for Joints, Immune Boost, and Plastic-Eating Fungi,

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