Mushrooms supply ergothioneine, a natural antioxidant that can bind and remove acrolein, a toxic byproduct of normal metabolism linked to chronic disease. This study showed that ergothioneine worked even better when paired with GABA, boosting acrolein capture by up to 200% in mice, and the same detox effect was confirmed in humans. Whether taken as a supplement or delivered through whole mushrooms like porcini (Boletus edulis), the combination helped the body safely eliminate acrolein through urine and feces, pointing to mushrooms as a practical way to reduce everyday toxic stress.