Mood & Mental Health

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Study

Non-Hallucinogenic Compound Matched Psilocybin for Neuroplasticity

Non-Hallucinogenic Compound Matched Psilocybin for Neuroplasticity

Psilocybin mushrooms

What they found

Zalsupindole boosted prefrontal neuroplasticity as well as psilocybin and ketamine without hallucinations, in preclinical tests.

Zalsupindole boosted prefrontal neuroplasticity as well as psilocybin and ketamine without hallucinations, in preclinical tests.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

zalsupindole; psilocybin; ketamine

zalsupindole; psilocybin; ketamine

Published in

ACS Chemical Neuroscience

ACS Chemical Neuroscience

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Trip-Free Therapy

Trip-Free Therapy

A new compound called zalsupindole boosted neuroplasticity in the prefrontal cortex as effectively as psilocybin and ketamine—without causing hallucinations or dissociation. In preclinical tests, it produced rapid and sustained antidepressant-like effects.

A new compound called zalsupindole boosted neuroplasticity in the prefrontal cortex as effectively as psilocybin and ketamine—without causing hallucinations or dissociation. In preclinical tests, it produced rapid and sustained antidepressant-like effects.

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