Mood & Mental Health

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Study

One Psilocybin Dose Helped Veterans With Treatment-Resistant Depression

One Psilocybin Dose Helped Veterans With Treatment-Resistant Depression

Psilocybin mushrooms

What they found

A single 25mg psilocybin dose helped 60% of 15 veterans with severe depression improve and 53% reach remission at 3 weeks.

A single 25mg psilocybin dose helped 60% of 15 veterans with severe depression improve and 53% reach remission at 3 weeks.

The number

60% of veterans with severe treatment-resistant depression achieve significant improvement and 53% reach remission after 3 weeks

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

15 participants

15 participants

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Veterans Respond Well to Psilocybin

Veterans Respond Well to Psilocybin

Single 25mg psilocybin doses helped 60% of veterans with severe treatment-resistant depression achieve significant improvement and 53% reach remission after 3 weeks in a study of 15 participants. Benefits proved durable, with 47% maintaining improvement and 40% remaining in remission at 12 weeks. Having PTSD didn't interfere with treatment success and the treatment proved safe with no unexpected side effects.

Single 25mg psilocybin doses helped 60% of veterans with severe treatment-resistant depression achieve significant improvement and 53% reach remission after 3 weeks in a study of 15 participants. Benefits proved durable, with 47% maintaining improvement and 40% remaining in remission at 12 weeks. Having PTSD didn't interfere with treatment success and the treatment proved safe with no unexpected side effects.

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